SPRAVATO® (esketamine) is an FDA-approved nasal spray designed for adults with treatment-resistant depression (TRD). Unlike traditional antidepressants that target serotonin and dopamine, SPRAVATO® works on NMDA receptors, helping to restore balance in brain function and providing relief for those who have not responded to standard treatments.

SPRAVATO® is intended for adults with treatment-resistant depression who have tried at least two different oral antidepressants without sufficient improvement. As of January 2025, the FDA has approved SPRAVATO® as a standalone treatment, meaning it no longer requires combination therapy with oral antidepressants. A consultation with a provider at NY Ketamine Infusions will determine if SPRAVATO® is right for you.

Each session takes place in a comfortable, supervised setting at NY Ketamine Infusions. You will self-administer the nasal spray under medical supervision. Afterward, you will be monitored for at least two hours for any potential side effects before being cleared to leave.

Many patients report feeling relief within 24 hours of their first few treatments. However, results vary, and a full treatment plan typically involves an induction phase (twice weekly for four weeks) followed by a maintenance phase based on your progress.

Common side effects include temporary dizziness, nausea, drowsiness, or dissociation (feeling detached from reality). These effects usually subside within a few hours. To ensure safety, patients are monitored closely during and after treatment.

No. Due to possible sedation and dissociation effects, you must arrange for someone to drive you home after each session. Patients should also avoid operating heavy machinery for the rest of the day.

The treatment schedule typically includes two sessions per week for the first four weeks, followed by a tapered maintenance phase depending on individual response. Your provider will tailor a plan based on your needs.

Coverage for SPRAVATO® is available through many leading insurance companies, though the extent of coverage can differ depending on your specific plan. At NY Ketamine Infusions, their dedicated team will help you confirm your insurance benefits and work to reduce your out-of-pocket expenses as much as possible.

SPRAVATO® is FDA-approved for standalone use and covered by insurance, whereas IV ketamine infusions are often out-of-pocket expenses. Additionally, SPRAVATO® is administered as a nasal spray in a certified treatment center, while ketamine infusions require an IV.

To begin treatment, schedule a consultation with NY Ketamine Infusions. Our team will evaluate your medical history, confirm eligibility, and create a personalized treatment plan to help you find relief from depression.